COVID-19 Update: Supplements to Suppress Pro-Inflammatory Cytokines BEFORE Late-Stage Severe Coronavirus Infection Sets In

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Patients with severe COVID-19 infection can develop fatal lung damage from a cytokine storm, a marked increase in pro-inflammatory cytokines such as Tumor Necrosis Factor-alpha (TNF-alpha), Interleukin-1 beta (ILB1), Interleukin-6 (IL6), Interleukin-8 (IL8) and other cytokines 

The following supplements can help to suppress the multiple pro-inflammatory cytokines that cause severe lung damage (ARDS) in patients with COVID-19 infection caused by coronavirus 2 or SARS-CoV-2.

NOTE: Sambucus Nigra (Elderberry):

There is evidence that elderberry inhibits replication and viral attachment of Human coronavirus NL63 (HCoV-NL63), different than COVID-19, but a member of the coronavirus family. (1). Sambucus appears most effective in the prevention or early stage of coronavirus infections. Sambucus significantly increases inflammatory cytokines, including IL-B1 so it should be discontinued with symptoms of infection (or a positive test) despite its ability to decrease TNF-alpha.

*See also “Will Elderberry Induce a Cytokine Storm?”

  • IL8 inhibitors: Cordyceps, ECGC (from green tea), Isatis spp, NAC, Polygonum cuspidatum
  • IL 8 (aka CXCL8): produced by macrophages and epithelial cells, airway smooth muscle cells, and endothelial cells. Induces the migration of neutrophils.
  • IL Beta-1: produced by activated macrophages. Stimulates cell proliferation differentiation and apoptosis. Upregulates COX2 in CNS
  • IL Beta-1 Inhibitors: Cordyceps, Eupatorium perfoliatum (boneset) Polygonum cuspidatum (Japanese knotweed), Salvia miltiorrhiza (red sage), Scutellaria baicalensis (skullcap).
  • IL 6: crosses the blood-brain barrier (BBB) and stimulates the production of PGE2 in the hypothalamus altering the body’s temperature regulation process. Affects pituitary/adrenal/hypothalamus axis. It can cause damage to neurons in the central nervous system (CNS) and peripheral nervous system. Common in Alzheimer’s, MS, depression, lupus, cognitive decline, progressive hearing loss, decreased hippocampal function, seizures, and stroke.
  • Il 6 inhibitors: Andrographis paniculata, Salvia miltiorrhiza, Scutellaria baicalensis, Isatis spp
  • TNF-alpha produced by macrophages, lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF-alpha tends to be elevated in Alzheimer’s, depression, inflammatory bowel disease, and cancer. It is synergistic with IL 1 and IL 6, with similar effects on the hypothalamic/pituitary/adrenal axis (HPA axis), temperature regulation, appetite, liver function, and insulin resistance. It causes heat, swelling, pain, and redness.
  • TNF-alpha Inhibitors: Andrographis, Cannabis, Cordyceps, Eupatorium, Houttuynia, Sambucus, Scutellaria, Salvia, Zingiber off. (ginger)
  • NLRP3 inflammasome Inhibitors: Melatonin

 

The ideas and recommendations in this article are for informational purposes only. The contents are not intended to replace the advice of the reader’s own healthcare professional or physician. The treatments described in this article may have known and unknown side effects and health hazards. Each reader is solely responsible for his or her own healthcare choices and decisions. The author advises the reader to discuss these ideas with a healthcare professional or physician before trying them. The author does not accept any responsibility for any positive or adverse effects a person claims to experience, directly or indirectly, from the ideas and contents of this article.

Resources: 

1.  Weng, Jing-Ru et al. “Antiviral activity of Sambucus FormosanaNakai ethanol extract and related phenolic acid constituents against human coronavirus NL63.” Virus research vol. 273 (2019): 197767. doi:10.1016/j.virusres.2019.197767

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About the author

Dr Myriah Hinchey

Dr Myriah Hinchey

Dr Myriah Hinchey

Dr. Myriah Hinchey is the Owner & Medical Director of Tao Vitality, a licensed CT Naturopathic Physician, and an accomplished Lyme-Literate doctor.

Dr. Hinchey is also the owner and co-founder of Lymecore Botanicals, a MAPS Certified Clinician, as well as a licensed medical acupuncturist.

Dr. Hinchey practices integrative naturopathic medicine for the whole family and additionally specializes in the reversal and prevention of Chronic Disease, and has become a sought after Chronic Lyme Specialist, incorporating cutting-edge healing modalities. Her treatment practices rely heavily on the principals of Functional Medicine and Therapeutic Lifestyle Change (TLC) as well as biomedical treatment of neurodevelopmental disorders including Autism Spectrum Disorder, Pervasive Development Disorder, and ADHD. 

The ideas and recommendations in this article are for informational purposes only.

The contents are not intended to replace the advice of the reader’s own healthcare professional or physician. The treatments described in this article may have known and unknown side effects and health hazards. Each reader is solely responsible for his or her own healthcare choices and decisions. The author advises the reader to discuss these ideas with a healthcare professional or physician before trying them. The author does not accept any responsibility for any positive or adverse effects a person claims to experience, directly or indirectly, from the ideas and contents of this article.

The ideas expressed in this article are based on the author’s own experience.

The success the author expresses may or may not be replicated by another healthcare provider or individual. Any specific health claims about specific herbs or nutrients (e.g., herb or nutrient A treats condition B) are based on the authors observation only. For the most part, any health claims are not supported with human studies or may not be recognized as beneficial by most physicians.
 

Herbs & Supplements

The author does make functional claims about many herbs and supplements in this article. Regarding statements with functional and structural claims for each specific supplement or product, the author notes:
 
‡ These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
 

The information in this article is believed to be accurate and reliable at the time of publication, but the author and publisher make no representation or warranty as to the accuracy, completeness, or suitability of the information provided. The author and publisher expressly disclaim all liability for any damages or injury of any kind arising directly or indirectly from the use or reliance on the information provided in this article.

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